What is Nuclear Factor-Kappa Beta (NF-ĸB)?
Several scientific journals mention Nuclear Factor- Kappa Beta (NF-ĸB) is a transcription factor that plays an important role in the regulation of the immune system and inflammatory processes. NF-ĸB is found in the cytoplasm and can be activated by various cellular stimuli, such as oxidative stress due to excessive free radicals, physical stress, and foreign objects that enter the body (viruses and bacteria).
Under homeostatic conditions, NF-ĸB activation is a normal biological response of the body as a defense against various stimuli that harm the body. The activation of NF-ĸB will form a balanced immune system. Immune cells such as macrophages, lymphocytes, neutrophils which are also associated with NF-ĸB, will react in a balanced way in response to these stimuli, including forming cytokines. Cytokines will play a role in the immune system to protect the body from becoming sick.
Under certain conditions, excessive activation of NF-ĸB will cause an imbalance in the immune system in response. This imbalance also causes the release of inflammatory mediators, such as cytokines. Excessive cytokines will cause severe inflammation even in healthy organs. Severe inflammation or chronic inflammation has the potential to cause organ damage, organ failure, and even death if not treated properly.
The excessive release of cytokines due to an imbalance in the immune system is known as a cytokine storm. This cytokine storm can be found in autoimmune disorders and COVID-19.
Cytokine storms should immediately be given pharmacological therapy (drug therapy) to overcome severe inflammation and other symptoms that emerge in the affected organ. The usual treatments for patients with cytokine storms are immunosuppressant and anti-inflammatory drugs to treat severe inflammation, as well as other symptomatic therapies. Cytokine storms can also be prevented by regulating the activation of NF-ĸB thus forming a balance of the immune system.
The combined components of several products from Biotek Farmasi Indonesia have characteristics of regulation of NF-ĸB activation. Regulation of NF-ĸB will help balance the immune system and help overcome inflammation thereby maintaining the body's resistance to diseases. Products from Biotek Farmasi Indonesia are originator products, not imitating existing ones. They were developed based on years of research.
Further information about the products can be found in the product page.