What is GFR (Glomerulus Filtration Rate)?

What is GFR (Glomerulus Filtration Rate)?

One of the functions of the kidneys is to filter the remnants of metabolism in the body. If there is a decrease in kidney function under certain conditions, the kidneys cannot filter optimally, resulting in kidney failure. One of the diagnoses in patients with kidney failure can refer to the laboratory value of GFR (Glomerular Filtration Rate).

So, what exactly is this GFR? GFR (Glomerular Filtration Rate) is the average rate of the kidney's ability to filter every minute. GFR measurement is usually calculated by eGFR (estimated Glomerulus Filtration Rate) which is based on creatinine in blood, age, and gender. GFR can also be used to assess the severity of kidney failure.

According to CKD KDIGO (Chronic Kidney Disease Improving Global Outcomes), the following are the stages of chronic kidney failure based on GFR values:
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One of the causes of kidney failure is due to an imbalance between antioxidants and free radicals in the form of ROS (Reactive Oxygen Species) and RNS (Reactive Nitrogen) caused by chronic inflammation. The high number of free radicals in the body can trigger oxidative stress which, if prolonged, can cause damage to the mitochondria of the kidneys.

Damage to mitochondria results in reduced production of ATP (Adenosine Tri Phosphate) which is used as an energy source. Lack of ATP or cellular energy in the kidneys results in decreased kidney function, and can even worsen kidney damage. The symptoms of kidney failure in general are a decrease in urine volume, changes in urine color, pain when urinating, pain in the back of the abdomen that can radiate to the legs, and swelling in the legs.

One of the new breakthrough products from Biotek Farmasi Indonesia, called K-FIX, can be used to help ease urination caused by urinary tract disorders in accordance with the indications from BPOM.

K-FIX is a kidney regulator (a product that helps regulate kidney function). Scientific journals show that the composition of K-FIX has several advantages, namely increasing cellular energy/ATP (Adenosine Tri Phosphate) in kidney glomerular cells and having antioxidants that can reduce oxidative stress.

Some of these advantages provide benefits for its users, like helping to improve kidney function and helping to inhibit damage to kidney glomerular cells. Unlike other drugs whose mechanism of action is to regulate acid base in the kidneys, K-FIX works by increasing ATP/cellular energy directly in the renal glomerular cells so that it can improve the filtration function of the kidneys, which is characterized by an increase in GFR values.

Products from Biotek Farmasi Indonesia are originator products, not imitating existing ones. This product was developed based on years of research.

Further information about the product can be seen in the product menu.
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